Part of the sustainability of in-depth basic research is the use of powerful and validated animal models that are inexpensive. The ease of manipulation, inexpensive maintenance, genetic amenability, combined with the relatively simple nervous systems of invertebrates provides the opportunity to investigate universal questions that cannot easily be addressed in mammalian systems. Indeed, studies in these models have provided fundamental information about conserved neurobiology processes and molecular pathways underlying nervous system disorders. This symposium aims to highlight, through concrete examples, how the use of invertebrate models can contribute to the understanding of key biological phenomena. The session proposed will include talks on diverse topics with a common denominator: the use of different invertebrate models. Since key elements of the biology of neurons and circuits are highly conserved throughout the animal kingdom, the mechanisms exposed in this symposium are likely to be universally crucial. We combine leader PIs from Argentina and USA that, despite being young, have made key contributions to their specific fields. We think that this initiative will contribute to foster invertebrate neuroscience research in the region, and will expose the audience to a plethora of tools devoted to addressing fundamental biological questions.